Instrument Details

Make : Shimadzu LC-MS/MS 8045

Parts:Nexera X2 – HPLC
Shimadzu 8045 MS/MS
1.9 μm C18 Column
5 μm C18 Column
Labsolutions Software.

Mass range m/z 2 to 2,000
Resolution R < 0.7 u (FWHM)
Scan speed Max. 30,000 u/sec

Positive-negative ion polarity switching time 5 msec
MRM measurement speed Max. 555 channels/sec

Location: Central Laboratory for Instrumentation and Facilitation, University of Kerala, Karivattom campus. Trivandrum.

Fee Detailsand submission of application

For fee details, please visit The request form for the instrument shall be downloaded from Read the instructions given in form and at the bottom of the analysis rates page carefully before submitting application. Proper method and area focus on result has to be mentioned for accuracy of results.


LC-MS/MS (Liquid chromatography – Mass spectrometry/ Mass spectrometry) is a hyphenated technique in which an HPLC(High Performance Liquid Chromatography) is connected to a mass spectrometer .The technology involves use of an HPLC ,where in the individual components in a mixture are first separated based on their affinity with the mobile phase and stationary phase which is usually a silica based column followed by Ionisation and separation of ions (in MS) based on their mass/charge ratio. The ion source is also depending on nature of analyte i.e., polar or nonpolar. The results will be the mass numbers present in the sample.
The LCMS-8045 was designed to be robust. The heated ESI probe, high temperature heating block, heated desolvation line, drying gas, and focusing optics all act to maximize sensitivity and minimize contamination. This means long periods of continuous operation in the laboratory with reliable data collection, even with complex biological fluids or food samples. Equipped with a heated ESI probe, the LCMS-8045 has the highest* sensitivity in its class. The instrument is capable of providing accurate and stable data overlong periods of time. The inclusion of Shimadzu’s ultra-high-speed* high-voltage power supply enables the world’s fastest scan speed (30,000 u/s) and polarity switching time (5 ms). High-speed acquisition benefits the laboratory by reducing run times for increased throughput, and also shortens method development time. LabSolutions LCMS features an intuitive user interface, and offers the latest features designed to enhance laboratory productivity and streamline workflows. Numerous pre-configured MRM method packages are available. Predetermined separation conditions and MRM parameters allow analysis to be started without long hours of method development, enhancing the efficiency of your laboratory.


Broad classification include food, pharmaceutical and environment applications. In detail, Screening of phytochemical from plants, Analysis of pesticides in plants and water bodies, Analysis of drug metabolism & toxicology studies, Study of steroid hormones., Study of vitamins and related metabolite etc


The user needs to have knowledge of proper method for the nalysis they required and target mass numbers. They know about the adduct ion formations. These things to be mentioned in request form. In the absence of this knowledge, a method development step become necessary with take long period of time.